Tuvan Syndrome (First Splinter)

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A neurological disease similar to Alzheimer's disease that affects Romulans, Tuvan Syndrome first steals its victim's motor skills, then ravages their mind. In time, a Romulan afflicted with the disease would grow incapable of recognizing loved ones, eventually resulting in the patient's lingering, debilitating death.[1]

References
  1. "Plagues of Night". Star Trek: Typhon Pact. Novel. Simon & Schuster/Pocket Books, May 2012.