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From Trekipedia
January
- January 10: After the death of his father, Ensign Mayweather visits his family on their cargo ship, the E.C.S. Horizon, and begins to reconsider his place aboard Enterprise. (ENT 46)
- January 21: Due to the demands of a militant faction, Enterprise is asked to retrieve a group of Denobulan geologists from an alien cave. (ENT 47)
- Unknown: Enterprise encounters the Vissians and Commander Tucker finds himself troubled by the fact that the species' third sex, the Cogenitor, is denied any rights. (ENT 48)
March
- March 1: A group of Borg are revived after a century frozen in the Arctic ice on Earth. (ENT 49)
- March 10: Upon the death of a close friend, A.G. Robinson, Captain Archer tells Sub-Commander T'Pol about his early career as an experimental warp engine test pilot. (ENT 50)
- March 21: A Tellarite, Skalaar, captures Captain Archer in the hope of collecting a reward from the Klingons, who have been searching for him since his escape from Rura Penthe. (ENT 51)
- March 22: The Xindi attack Earth. (ENT 52)
April
- April 24: Enterprise, having been recalled to Earth following the Xindi attack, is refitted before being sent into the Delphic Expanse. Sub-Commander T'Pol resigns her commission with the Vulcan High Command, and Commander Tucker is troubled by the death of his sister, Elizabeth. (ENT 52)
June
- June 26: Enterprise enters the Delphic Expanse. Duras is killed in combat, trying to bring Archer to face Klingon justice. (ENT 52, Epilogue)
September
- September 8: Captain Archer and Lieutenant Reed visit a mining facility in order to track down a Xindi. (ENT 53)
- September 29: The crew of Enterprise encounters the rigors of the Delphic Expanse first-hand, and deal with pirates operating from a giant cloaked alien sphere. (ENT 54)
October
- Unknown: While pursuing the Xindi, Archer, Reed, and Sato are exposed to an alien virus and begin to mutate into Loque'eque, a long-dead alien race. (ENT 55)
- Unknown: Rajiin, a slave girl whom Archer rescues from an alien bazaar, seeks refuge aboard Enterprise, only to betray the crew. (ENT 56)
- Unknown: Enterprise encounters a Vulcan ship whose crew has become unstable due to exposure to the compound Trellium-D. Commander T'Pol soon begins to exhibit the same symptoms. (ENT 57)
- Unknown: A telepathic alien offers to help the Enterprise crew, but only if Sato remains on his planet with him.(ENT 58)
November
- Unknown: Captain Archer learns of kemocite, a key element in the weapon being built to destroy Earth, and seeks to follow its supply to the superweapon. (ENT 59)
- Unknown: A parasite causes Captain Archer to lose his long-term memory, and in the future, he (with the help of T'Pol and Doctor Phlox) seeks a way to change the past. (ENT 60)
- Unknown: Investigating a planet found to be inhabited by Humans, the crew find what appears to be a town from the American West of the 19th century. (ENT 61)
- Unknown: Commander Tucker becomes comatose after an accident, and a rapid-growing clone, named Sim, is created for the purpose of harvesting brain tissue. (ENT 62)
- Unknown: With the help of Temporal Agent Daniels, Captain Archer and Commander T'Pol go back to 2004 Detroit to stop a group of Xindi Reptilians from releasing a biological weapon. (ENT 63)
- Unknown: Religious zealots seek to execute Captain Archer, for supposed acts of sphere desecration, after hijacking Enterprise. (ENT 64)
December
- December 6: Xindi scientists test their new, planet-killing weapon in an asteroid field as Captain Archer is suddenly assisted by Andorians, led by Shran, in the Delphic Expanse. (ENT 65)
- December 12: A Xindi scientist, Degra, is tricked into giving Captain Archer information about the location of the new superweapon. (ENT 66)
- December 27: Enterprise encounters a dying alien, one of the Sphere Builders, for the first time. (ENT 67)