Challenger
From Trekipedia
There have been several ships named Challenger.
Space Shuttle Challenger OV-103 (NASA, destroyed 1986)
Challenger NX-03 (NX class, 2155-2156)
U.S.S. Challenger (Ranger class, c.2215)
U.F.F. Challenger (c.2275)
U.S.S. Challenger (Challenger (II) class, c.2357)
U.S.S. Challenger NCC-71099 (Galaxy class, c.2360)