2153 (Columbia)

January

• January 10: After the death of his father, Ensign Mayweather visits his family on their cargo ship, the E.C.S. Horizon, and begins to reconsider his place aboard Enterprise. (ENT 46: "Horizon")
• Unknown: Chapter 12 (TOS #35: "The Romulan Way")
• January 21: Due to the demands of a militant faction, Enterprise is asked to retrieve Denobulan geologists from an alien cave. (ENT 47: "The Breach")

February

• Unknown: Enterprise encounters the Vissians and Commander Tucker finds himself troubled by the fact that the species' third sex, the Cogenitor, is denied any rights. (ENT 48: "Cogenitor")

March

• March 1: A group of Borg are revived after a century frozen in the Arctic ice. (ENT 49: "Regeneration")
• March 10: Upon the death of a close friend, Captain Archer tells Sub-Commander T'Pol about his early career as an experimental warp engine pilot. (ENT 50: "First Flight")
• Unknown: (ENT: "Daedalus")
• Unknown: (ENT: "Daedalus's Children")
• March 21: A Tellarite, Skalaar, captures Captain Archer in the hope of collecting a reward from the Klingons, who have been searching for him since his escape from Rura Penthe. (ENT 51: "Bounty")
• March 22: The Xindi attack Earth. (Teaser) (ENT 52: "The Expanse")

April

• April 24: Enterprise, having been recalled to Earth following the Xindi attack, is refitted before being sent into the Delphic Expanse. Sub-Commander T'Pol resigns her commission with the Vulcan High Command, and Commander Tucker is troubled by the death of his sister. (ENT 52: "The Expanse")
• Unknown: "Incursion" (Star Trek: Encounters) (ENT)
• Unknown: "Xindi Superweapon" (Star Trek: Encounters) (ENT)

June

• June 26: Enterprise enters the Delphic Expanse. Duras is killed in combat, trying to bring Archer to face Klingons justice. (Epilogue) (ENT 52: "The Expanse")

September-December

• September 8: Captain Archer and Lieutenant Reed visit a mining facility in order to track down a Xindi. (ENT 53: "The Xindi")
• Unknown: (ENT: "Last Full Measure")
• September 29: The crew of Enterprise encounters the rigors of the Delphic Expanse first-hand, and deal with pirates operating from a giant cloaked alien sphere. (ENT 54: "Anomaly")
• Unknown: "Earthquake Weather" (Strange New Worlds VII) (ENT)
• Unknown: While pursuing the Xindi, Archer, Reed, and Sato are exposed to an alien virus and begin to mutate into Loque'eque, a long-dead alien race. (ENT 55: "Extinction")
• Unknown: "Hero" (Strange New Worlds 8) (ENT)
• Unknown: A slave girl Archer rescues from an alien bazaar seeks refuge aboard Enterprise but betrays the crew instead. (ENT 56: "Rajiin")
• Unknown: Enterprise encounters a Vulcan ship whose crew has become unstable due to Trellium-D exposure. Commander T'Pol soon begins to exhibit the same symptoms. (ENT 57: "Impulse")
• Unknown: A telepathic alien offers to help the Enterprise crew, but only if Sato remains on his planet with him.(ENT 58: "Exile")
• Unknown: Captain Archer learns of Kemocite, a key element in the weapon being built to destroy Earth, and seeks to follow its supply to the superweapon. (ENT 59: "The Shipment")
• Unknown: A parasite causes Captain Archer to lose his long-term memory, and in the future, he (with the help of T'Pol and Doctor Phlox) seeks a way to change the past. (ENT 60: "Twilight")
• Unknown: Investigating a planet found to be inhabited by Humans, the crew find a town resembling the American "Old West". (ENT 61: "North Star")
• Unknown: Commander Tucker becomes comatose after an accident, and a rapid-growing clone is created for the purpose of harvesting brain tissue. (ENT 62: "Similitude")
• Unknown: With the help of Temporal Agent Daniels, Captain Archer and Commander T'Pol go back to 2004 Detroit to stop a group of Xindi Reptilians from releasing a biological weapon. (ENT 63: "Carpenter Street")
• Unknown: Religious zealots seek to execute Captain Archer, for supposed acts of sphere desecration, after hijacking Enterprise. (ENT 64: "Chosen Realm")
• December 6: Xindi scientists test their new, planet-killing weapon in an asteroid field as Captain Archer is suddenly assisted by Andorians in the Delphic Expanse. (ENT 65: "Proving Ground")
• December 12: A Xindi scientist, Degra, is tricked into giving Captain Archer information about the location of the new superweapon. (ENT 66: "Stratagem")
• December 27: Enterprise encounters a dying alien, one of the Sphere Builders, for the first time. (ENT 67: "Harbinger")

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