Reference Stardate 1/0300 through 1/0312
- January 10: After the death of his father, Ensign Mayweather visits his family on their cargo ship, the E.C.S. Horizon, and begins to reconsider his place aboard Enterprise. (ENT 46)
- Unknown: (TOS #35, Chapter 12)
- January 21: Due to the demands of a militant faction, Enterprise is asked to retrieve a group of Denobulan geologists from an alien cave. (ENT 47)
- Unknown: Enterprise encounters the Vissians and Commander Tucker finds himself troubled by the fact that the species' third sex, the Cogenitor, is denied any rights. (ENT 48)
- Unknown: Enterprise is pulled through a rift in spacetime to a parallel reality where the starship Daedalus was never destroyed.
- March 1: A group of Borg are revived after a century frozen in the Arctic ice on Earth. (ENT 49)
- March 10: Upon the death of a close friend, A.G. Robinson, Captain Archer tells Sub-Commander T'Pol about his early career as an experimental warp engine test pilot. (ENT 50)
- March 21: A Tellarite, Skalaar, captures Captain Archer in the hope of collecting a reward from the Klingons, who have been searching for him since his escape from Rura Penthe. (ENT 51)
- March 22: The Xindi attack Earth. (ENT 52, ENT: "Last Full Measure")
- April 24: Enterprise, having been recalled to Earth following the Xindi attack, is refitted before being sent into the Delphic Expanse. Sub-Commander T'Pol resigns her commission with the Vulcan High Command, and Commander Tucker is troubled by the death of his sister, Elizabeth. (ENT 52)
- Unknown: (ENT: ENC, "Incursion")
- Unknown: (ENT: ENC, "Xindi Superweapon")
- June 26: Enterprise enters the Delphic Expanse. Duras is killed in combat, trying to bring Archer to face Klingon justice. (ENT 52, Epilogue)
- RSD 0/7308.20 (20 August): First contact is officially made with the Tellarites when a single Tellarite patrol ship enters the Sol system and declares that the system has been annexed by the United Planets of 61 Cygni. Admiral Abel Niwen, commanding the Starfleet forces in the system, elects to diplomatically welcome the Tellarite vessel, while warning that any hostile action would be reciprocated. The Tellarite commander abruptly accepts what he sees as an offer of friendship and implied military alliance, thus beginning a long, successful relationship between the United Earth Republic and the United Planets of 61 Cygni. Admiral Niwen receives the Medal of Honor for his actions, and later retires from Starfleet to serve as Earth's first ambassador to Tellar.
- September 8: Captain Archer and Lieutenant Reed visit a mining facility in order to track down a Xindi. (ENT 53)
- Unknown: (ENT: "Last Full Measure")
- September 29: The crew of Enterprise encounters the rigors of the Delphic Expanse first-hand, and deal with pirates operating from a giant cloaked alien sphere. (ENT 54)
- Unknown: (ENT: SNW7, "Earthquake Weather")
- Unknown: While pursuing the Xindi, Archer, Reed, and Sato are exposed to an alien virus and begin to mutate into Loque'eque, a long-dead alien race. (ENT 55)
- Unknown: (ENT: SNW8, "Hero")
- Unknown: Rajiin, a slave girl whom Archer rescues from an alien bazaar, seeks refuge aboard Enterprise, only to betray the crew. (ENT 56)
- Unknown: Enterprise encounters a Vulcan ship whose crew has become unstable due to exposure to the compound Trellium-D. Commander T'Pol soon begins to exhibit the same symptoms. (ENT 57)
- Unknown: A telepathic alien offers to help the Enterprise crew, but only if Sato remains on his planet with him.(ENT 58)
- RSD 1/0311.02 (2 November): Outer Sector Defense Outpost 1, located near Delta II, is destroyed by a squadron of seven Romulan cruisers. Commodore Tonsum Han, commanding the 159th Combat Squadron, has his entire force out on maneuvers at the time of the attack. He is subsequently court-martialed and discharged for dereliction of duty.
- Unknown: Captain Archer learns of kemocite, a key element in the weapon being built to destroy Earth, and seeks to follow its supply to the superweapon. (ENT 59)
- Unknown: A parasite causes Captain Archer to lose his long-term memory, and in the future, he (with the help of T'Pol and Doctor Phlox) seeks a way to change the past. (ENT 60)
- Unknown: Investigating a planet found to be inhabited by Humans, the crew find what appears to be a town from the American West of the 19th century. (ENT 61)
- Unknown: Commander Tucker becomes comatose after an accident, and a rapid-growing clone, named Sim, is created for the purpose of harvesting brain tissue. (ENT 62)
- Unknown: With the help of Temporal Agent Daniels, Captain Archer and Commander T'Pol go back to 2004 Detroit to stop a group of Xindi Reptilians from releasing a biological weapon. (ENT 63)
- Unknown: Religious zealots seek to execute Captain Archer, for supposed acts of sphere desecration, after hijacking Enterprise. (ENT 64)
- December 6: Xindi scientists test their new, planet-killing weapon in an asteroid field as Captain Archer is suddenly assisted by Andorians, led by Shran, in the Delphic Expanse. (ENT 65)
- RSD 1/0312.06 (6 December): Starfleet Command institutes a mobilization alert to bring all bases and construction facilities to combat readiness. As a part of the mobilization alert, a Zone of Transport Escort is established. Starfleet assigns military escorts to all priority transports.
- December 12: A Xindi scientist, Degra, is tricked into giving Captain Archer information about the location of the new superweapon. (ENT 66)
- December 27: Enterprise encounters a dying alien, one of the Sphere Builders, for the first time. (ENT 67)
- Stern, Dave. Daedalus. Star Trek: Enterprise. Pocket Books, December 2003.
- Stern, Dave. Daedalus's Children. Star Trek: Enterprise. Pocket Books, May 2004.
- Goldstein, Stan and Goldstein, Fred with Sternbach, Rick. Star Trek: Spaceflight Chronology. Pocket Books, 1980.
- Theisen, John A. "Where Has All the Glory Gone?" Star Trek: The Role Playing Game, Supplement 2217. Illustrations by David Dietrick, Jane Bigos, and Dana Knutson. FASA Corporation. 1985.
- Theisen, John A. "The Romulan War." Star Trek: The Role Playing Game, Supplement 2221A. Illustrations by Cliff Van Meter and Dana Knutson. FASA Corporation. 1986.