- Reference Stardate 2/0700: Armed conflict erupts between the United Federation of Planets and the Klingon Empire. Both sides suffer heavy casualties and begin preparing for full-scale war. Starfleet Intelligence later learns that Klingon Thought Admiral Krador zantai Rrilac has been reassigned to a military governorship on Muldor IV.
- Reference Stardate 2/0702: The Derf class tender U.S.S. Acropolis responds to a malfunctioning navigational marker buoy. A Klingon warship attacks, crippling the Acropolis, and tows it into Klingon space. Starfleet Intelligence later learns that the Klingons tampered with the buoy, producing the false signal.
- c.Stardate 1000/Reference Stardate 2/0704 (approx. 13 May): The U.S.S. Enterprise NCC-1701 begins its Five Year Mission under Captain James T. Kirk, following the promotion of Captain Christopher Pike to the position of Fleet Captain over Constitution class starships.
- Reference Stardate 2/0705: As a result of the danger posed by the new Klingon base at Mastocal, Federation Starbase 12 is completed and assumes operational status.
- Stardate 1256.9 (approx. 14 August): The Daedalus class Starfleet Corps of Engineers ship U.S.S. Lovell NCC-470 is assigned to provide engineering support to Starbase 47, aka "Vanguard."
- Stardate 1271.4 (approx. 20 August): Construction of Starbase 47, aka Vanguard, is completed.
- Stardate 1312.4/Reference Stardate 2/0705 (approx. 4 September): After the Enterprise attempts to cross the Galactic Barrier at the edge of the galaxy, crew members Gary Mitchell and Elizabeth Dehner develop "godlike" psychic powers which threaten the safety of the crew.
- Stardate 1321.6 (approx. 9 September): The Enterprise docks at Starbase 47 for repairs, following the incident at the Galactic Barrier.
- Stardate 1329.1 (approx. 10 September): The Enterprise pursues a vessel and rescues its occupants: interstellar con man Harry Mudd, who is arrested on outstanding charges, and three incredibly beautiful women, his cargo. After Kirk diverts to a mining planet to obtain new dilithium crystals for the Enterprise, Mudd negotiates with the three miners there, exchanging the women for his own profit. Finally, Mudd's deception is revealed as the women are, in fact, taking an illegal Venus drug. Kirk obtains the crystals he needs and takes Mudd back into custody.
- Stardate Unknown
- Stardate 1512.2 (approx. 15 November): The Enterprise is menaced by a gigantic alien ship whose commander condemns the crew to death. The alien ship appears all-powerful and the alien commander refuses all attempts at negotiation, forcing Kirk to employ an unorthodox strategy to save the ship.
- Stardate 1528.4 (approx. 21 November): (6 weeks after "Summon the Thunder", date given in "Open Secrets")
- Stardate 1531.1 (approx. 22 November): The Enterprise visits planet M-113 for a routine medical inspection of the husband-wife archaeological team stationed there, but the crew finds that the wife has been replaced by a deadly, shape-shifting creature.
- Stardate 1533.6 (23 November): While traveling aboard the Enterprise, a dangerous young man named Charlie Evans terrorizes the crew with his unusual mental powers.
- Stardate1573.9 (approx. 30 November): (3 weeks after "Reap the Whirlwind")
- 25 December: Captain Kirk meets Dr. Helen Noel at the science lab Christmas party. They dance, and Kirk talks with her about the stars.
Captain Kirk's five-year mission was established to have begun in 2265 in the Star Trek: Voyager episode "Q2". The Star Trek episode "The Menagerie, Part I" further establishes that Spock served under Captain Pike for 11 years, and that it had been 13 years since the events of "The Cage," meaning that Stardate 3012.4 fell two years into Kirk's command. The episode "Charlie X" further added weight to this, establishing both Stardate 1533.1 and the Earth date of Thanksgiving, which falls on 23 November in 2265. As the stardates ranged from the mid-1000s to the low 3000s in the first season and continued to increase at approximately 1000 per season afterward, it seems logical to conclude that the first season spanned nearly two years, and later seasons one each, with the second season chronicling the 3000s, the third season the 4000s and 5000s, and the Animated Series the 5000s. If Captain Kirk's command began on or about Stardate 1000, this would put the end of the five year mission on or about Stardate 6000, shortly after the end of the Animated Series. Using these dates as a reference point, the following can be established:
- Stardate 1000 fell on 13 May 2265.
- The range for Stardates each year is from X636 to Y635 (e.g., 1636 to 2635)
- This places "The Menagerie" (Stardate 3012.4) on 18 May 2267, at the beginning of Kirk's third year in command of the Enterprise
- Barton, William A., Gallagher, Tara J., Hess, Clare W. III, Huettel, Todd W., Kemper, Dale L., Menke, Bernard Edward, Pardoe, Blaine L., Peterson, Boy F., Rogan, Peter R., Stein, Kevin, Stuart, Rick David, and Theisen, John A. "Star Trek IV: The Voyage Home Sourcebook Update." Star Trek: The Role Playing Game, Supplement 2224. FASA Corporation. 1986.
- Roddenberry, Gene (Executive Producer). "The Menagerie, Part I." Star Trek, Season 1, Episode 15. Directed by Marc Daniels and Robert Butler. Written by Gene Roddenberry. Desilu Productions, 17 November 1966.
- Berman, Rick & Biller, Kenneth (Executive Producers). "Q2." Star Trek: Voyager, Season 7, Episode 19. Directed by LeVar Burton. Story by Kenneth Biller. Teleplay by Robert Doherty. Paramount Pictures Corporation, 11 April 2001.
- Wheeler, Wm. John with McLimore, Guy W. Jr., Poehlein, Greg K., and Tepool, David F. "Cadet's Orientation Sourcebook." Star Trek: The Role Playing Game, Book 2004A. FASA Corporation, 1983.
- Ward, Dayton, Dilmore, Kevin, Palmieri, Marco, and Mack, David. "Declassified." Star Trek: Vanguard, Book 6. Pocket Books, June 2011.
- Ward, Dayton. "What's Past, Book Four: Distant Early Warning." Star Trek: S.C.E., Book 64. Pocket Books, June 2006.
- Mack, David. "Harbinger." Star Trek: Vanguard, Book 1. Pocket Books, July 2005.
- Roddenberry, Gene (Executive Producer). "Where No Man Has Gone Before." Star Trek, Season 1, Episode 1. Directed by James Goldstone. Written by Samuel A. Peeples. Desilu Productions, 22 September 1966.
- Roddenberry, Gene (Executive Producer). "Mudd's Women." Star Trek, Season 1, Episode 3. Directed by Harvey Hart. Story by Gene Roddenberry. Written by Stephen Kandel. Desilu Productions, 13 October 1966.
- Ward, Dayton and Dilmore, Kevin. "Summon the Thunder." Star Trek: Vanguard, Book 2. Pocket Books, June 2006.
- Roddenberry, Gene (Executive Producer). "The Corbomite Maneuver." Star Trek, Season 1, Episode 2. Directed by Joseph Sargent. Written by Jerry Sohl. Desilu Productions, 10 November 1966.
- Mack, David. "Reap the Whirlwind." Star Trek: Vanguard, Book 3. Pocket Books, May 2007.
- Roddenberry, Gene (Executive Producer). "The Man Trap." Star Trek, Season 1, Episode 5. Directed by Marc Daniels. Written by George Clayton Johnson. Desilu Productions, 8 September 1966.
- Roddenberry, Gene (Executive Producer). "Charlie X." Star Trek, Season 1, Episode 7. Directed by Lawrence Dobkin. Story by Gene Roddenberry. Teleplay by D.C. Fontana. Desilu Production, 15 September 1966.
- Ward, Dayton. "Open Secrets." Star Trek: Vanguard, Book 4. Pocket Books, April 2009.
- Roddenberry, Gene (Executive Producer). "Dagger of the Mind." Star Trek, Season 1, Episode 10. Directed by Vincent McEveety. Written by S.Bar-David. Desilu Productions, 3 November 1966.